RESUMO
Acute myeloid leukemia is an aggressive malignant neoplasm occurring mainly in elderly, with the median age of 65 years. Oral manifestations, mainly spontaneous bleeding, are a common finding in acute myelocytic leukemia and may represent the initial evidence of the disease. This report describes a case of a 47-year-old man with a one-month history of spontaneous oral bleeding. The patient had already been consulted by two professionals but he remained undiagnosed. The physical examination revealed paleness, fever, epistaxis and ecchymoses in the oral mucosa. The complete blood count revealed anemia, severe thrombocytopenia and leukocytosis with blasts predominance, reinforcing the diagnosis hypothesis of an acute leukemia. The patient was immediately referred to the Hospital and despite having received a quick intervention, he died 3 days after the admission due to diffuse pulmonary alveolar hemorrhage. According to the peripheral blood immunophenotyping the diagnosis of hypogranular variant of acute promyelocytic leukemia was established. The delay in the diagnosis may have influenced the unfavorable outcome. Early diagnosis and management are indispensable for survival of leukemia patients. In this way, dentists may be responsible for an early detection of oral manifestations of leukemia and for a fast referral to an adequate professional.
RESUMO
O objetivo do presente trabalho é revisar a literatura a respeito do subgalato de bismuto na realização da hemostasia e prevenção de hemorragia pós-operatória, bem como relatar um caso clínico de um paciente submetido à exérese de hiperplasia papilomatosa com a utilização do subgalato de bismuto como agente hemostático local. Descrição do caso: Paciente do gênero feminino, 51 anos, procurou atendimento apresentando lesões em palato duro. Relatou utilizar prótese total superior há 20 anos, que apresentava em mal estado de higiene, com áreas de desgastes e estava mal adaptada no rebordo alveolar da paciente. Na avaliação intrabucal foi observado diversas pápulas medindo de 2 a 5mm de diâmetro, de coloração avermelhada, forma arredondadas, superfície lisa e consistência fibrosa. A hipótese diagnóstica foi de hiperplasia papilomatosa e o plano de tratamento incluiu a remoção da prótese do paciente por 14 dias, para regressão do quadro inflamatório local e biópsia excisional. Após o procedimento cirúrgico foi aplicado o subgalato de bismuto a 100%, em pó, diretamente no palato e a prótese total foi utilizada para proteção do sítio cirúrgico. Foi observado um bom estado de cicatrização tecidual no pós-operatório e a paciente relatou ausência de complicações. Na literatura, não foi encontrado relato de casos semelhantes, no entanto, o subgalato tem sido utilizado em cirurgias de tonsilectomias palatinas com o mesmo intuito e também é visto sua utilidade como hemostático local e tem a vantagem de ser um instrumento acessível nos serviços públicos de saúde
The purpose of this paper is to review the literature of bismuth subgalate for hemostasis and prevention of post-operative bleeding and report a case of a patient undergoing papillomatous hyperplasia excision with the use of bismuth subgalate as local hemostatic agent. Case report: female patient, 51, sought treatment with lesions on the hard palate. Reported use denture higher 20 years ago, which showed in bad conditions of hygiene, with areas of wear and was ill-suited in the alveolar ridge of the patient. In intraoral evaluation was observed several papule 2 to 5mm in diameter, red in color, round in shape, smooth surface and fibrous consistency. The diagnosis was papillomatous hyperplasia and the treatment plan included removal of the patients prosthesis for 14 days, regression to the local inflammatory process and excisional biopsy. After the surgical procedure has been applied bismuth subgallate 100%, in powder form, directly in the palate and the denture was used to protect the surgical site. A good state of tissue healing after surgery and the patient reported no complications were observed. In the literature, it has not found any report of similar cases, however, the subgalate has been used in palatine tonsillectomy surgery with the same purpose and is also seen its usefulness as a local hemostatic and has the advantage of being a handy tool in public health services
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Cirurgia Bucal , Dentaduras , Palato Duro/patologia , Papiloma , Biópsia , HiperplasiaRESUMO
Os estudos epidemiológicos perfazem uma grande área da pesquisa desempenhando um importante papel, pois revelam a prevalência de inúmeras doenças e particularizam a sua distribuição dentro de características próprias do ambiente onde estão sendo desenvolvidos. Assim, o objetivo desse trabalho foi o de analisar o perfil epidemiológico de acordo com os laudos histopatológicos dos pacientes atendidos no serviço de Estomatologia, através do projeto de Extensão Diagnóstico e Tratamento de Lesões de Interesse Estomatológico e Prevenção de Câncer Bucal da Universidade Estadual de Londrina, entre 2008 a 2012. A análise de 527 espécimes biopsiados revelou 183 casos em homens e 344 em mulheres. Adicionalmente, a idade variou de 5 meses de vida a 108 anos. A hiperplasia fibrosa inflamatória foi a lesão mais comum (49,5%), seguida de, mucocele (11,1%), papiloma (8,1%), carcinoma espinocelular (3,8%) e granuloma piogênico (3%)
Epidemiological studies make up a large area of research playing an important role, because they reveal the prevalence of many diseases and particularize its distribution characteristics within the environment where they are being developed. The objective of this study was to analyze the epidemiological profile in accordance with histopathological results from patients treated at the Stomatology Department, through the project Diagnosis and Treatment of Injuries of Interest Dental and Oral Cancer Prevention at the State University of Londrina between 2008 to 2012. The analysis of 527 biopsy specimens revealed 183 cases in men and 344 in women. Additionally, the age ranged from 5 months to live to 108 years. The inflammatory fibrous hyperplasia was the most common lesion (49.5%), followed by, mucocele (11.1%), papilloma (8.1%), squamous cell carcinoma (3.6%) and pyogenic granuloma (3%)
Assuntos
Humanos , Masculino , Feminino , Biópsia , Diagnóstico Bucal , Mucosa Bucal , Mucosa Bucal/lesõesRESUMO
BACKGROUND: The capacity for DNA repair is essential in maintaining cellular functions and homeostasis; however, this capacity can be altered based on DNA sequence variations in DNA repair genes, which may contribute to the onset of cancer. Many single-nucleotide polymorphisms (SNPs) in repair genes have been found to be associated with oral cancer. The aim of this study was to investigate the relationship between the presence of allelic variants Arg194Trp (rs:1799782) and Arg399Gln (rs: 25487) of XRCC1 gene and Thr241Met (rs: 861539) of XRCC3 gene and susceptibility to oral cancer. We also attempted to correlate the frequencies obtained for each of the SNPs to histopathological parameters. METHODS: A case-control study was conducted with genomic DNA from 150 patients with oral squamous cell carcinomas and 150 controls. SNPs were genotyped by RFLP-PCR. RESULTS: The presence of the polymorphic variants of the XRCC1 gene within codon 194 (OR 0.82, 95% CI: 0.44-1.51) and codon 399 (OR 0.94, 95% CI: 0.59-1.50) and within the XRCC3 gene (OR 0.72; 95% CI: 0.45-1.16) were not associated with an increased risk of oral cancer. A combinational analysis of SNPs in both genes indicated no association. The presence of the allelic variants of these two genes had no statistically significant effect on tumor differentiation, lymph node invasion or tumor size. CONCLUSIONS: These results suggest that allelic variants of XRCC1 and XRCC3 are not suitable markers for susceptibility to carcinomas of the oral cavity and are also not related to the later stages of such tumors.
Assuntos
Alelos , Carcinoma de Células Escamosas/genética , Reparo do DNA/genética , Proteínas de Ligação a DNA/genética , Predisposição Genética para Doença/genética , Variação Genética/genética , Neoplasias Bucais/genética , Adulto , Idoso , Idoso de 80 Anos ou mais , Arginina/genética , Carcinoma de Células Escamosas/patologia , Estudos de Casos e Controles , Códon/genética , Feminino , Frequência do Gene/genética , Genótipo , Glutamina/genética , Humanos , Metástase Linfática/genética , Masculino , Metionina/genética , Pessoa de Meia-Idade , Neoplasias Bucais/patologia , Polimorfismo Genético/genética , Polimorfismo de Nucleotídeo Único/genética , Fatores de Risco , Treonina/genética , Triptofano/genética , Proteína 1 Complementadora Cruzada de Reparo de Raio-X , Adulto JovemRESUMO
Relata um caso de condroblastoma benigno, comenta as características clínicas, anátomo patológicas, terapêuticas e prognóstico da lesäo, baseado em informaçöes da literatura
